Second-generation fluorous chiral (salen) manganese complexes
نویسندگان
چکیده
منابع مشابه
Prevention of Nonalcoholic Steatohepatitis in Rats by Two Manganese-Salen Complexes
Background: Nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), is characterized by steatosis with inflammation. Investigations have suggested that oxidative stress may play an important role in the progress of NAFLD to NASH. To provide further insights into beneficial effects of antioxidants in NASH prevention, we employed two manganese-supero...
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Chiral spectroscopic study: The intensities of second harmonic generation chiral spectroscopy are obtained from the dispersion of the nonlinear optical susceptibility components, as a function of wavelength for helicenbisquinone thin films (see figure). A single formalism fits all the data simultaneously, and the findings constitute an important milestone towards the development of a new experi...
متن کاملApoptosis and anti-tumour activities of manganese(III)-salen and -salphen complexes.
We analyzed the apoptosis and anti-tumour activities of several Mn(III)-salen and -salphen complexes (1-14) towards three different cultured human cancer and non-cancer cells. We demonstrated that most of the Mn(III)-salen and -salphen complexes affect cell viability and induce apoptosis in MCF7 cells. Biochemically active Mn(III)-salen and -salphen complexes induced nuclear fragmentation and r...
متن کاملSalen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies.
Synthetic catalytic scavengers of reactive oxygen species (ROS) may have broad clinical applicability. In previous papers, two salen-manganese complexes, EUK-8 and EUK-134, had superoxide dismutase (SOD) and catalase activities and prevented ROS-associated tissue injury. This study describes two series of salen-manganese complexes, comparing catalytic ROS scavenging properties and cytoprotectiv...
متن کاملprevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes
background: nonalcoholic steatohepatitis (nash), a progressive stage of nonalcoholic fatty liver disease (nafld), is characterized by steatosis with inflammation. investigations have suggested that oxidative stress may play an important role in the progress of nafld to nash. to provide further insights into beneficial effects of antioxidants in nash prevention, we employed two manganese-superox...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2000
ISSN: 1359-7345,1364-548X
DOI: 10.1039/b007053j